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Tarceva® erlotinib tablets
Considering Tarceva

Pancreatic Cancer Treatment Options

Various treatments are used to treat cancer of the pancreas, including surgery, radiation, chemotherapy alone and chemotherapy with a targeted treatment. Depending on the stage of the cancer, your doctor may combine some of these treatments. Some of these options are explained in this section.

The chemotherapy drug gemcitabine is the most common treatment used for advanced pancreatic cancer that has spread. A large clinical study proved that taking Tarceva (erlotinib) while receiving gemcitabine is another option for treating pancreatic cancer.

Treatment How does it work? When may this treatment be used?
Surgery

Surgery to remove the tumor offers the best chance for long term control of all types of pancreatic cancer.

In general, a tumor is considered resectable if it has not spread (metastasized) beyond the pancreas and does not involve major blood vessels. About 15% of pancreatic adenocarcinoma is considered surgically resectable at the time of diagnosis. This can be done if the tumor is small and has not spread to other areas of your body.

You should be in good overall health to have surgery. Surgery can be the first step in your treatment plan. It may be performed in patients with Stage I-III.

Radiation

Uses high-energy x-ray beams to shrink the tumor.

Radiation may destroy cancer cells remaining after surgery. Radiation may be given alone or in combination with chemotherapy or other treatments. The chemotherapy drugs most commonly used in conjunction with radiation therapy are fluorouracil (5-FU) and gemcitabine.

This may be done before surgery to make it easier to remove the tumor. Radiation can also be done after surgery.

This treatment may be used in Stage II-III. However, it can also be used to shrink tumors in advanced pancreatic (Stage IV) to ease pain.

Your overall health may not be good enough for you to have surgery. Or, the cancer may have spread to other areas in your body. If so, radiation treatment may be used instead of surgery.

Chemotherapy

Drugs used to destroy or slow the growth of cancer cells.

Chemotherapy may be used with radiation to help shrink the tumor before surgery.

It may be used after surgery or radiation to destroy any cancer cells that may have been left behind.

Targeted Therapy

Designed to affect only certain cancer cell activities. Helps slow the tumor growth and destroy cancer cells.

May be used in combination with chemotherapy in first-line treatment.

To learn more, please visit our Pancreatic Cancer Resource Center to find links to organizations that provide information and support to cancer patients and their caregivers.

Indication and Usage for Advanced Pancreatic Cancer Patients

Tarceva in combination with gemcitabine is prescribed for patients with advanced-stage pancreatic cancer who have not received previous chemotherapy.

Important Safety Information

Possible effects on the lungs

In clinical studies, there were infrequent reports of lung injuries similar to Interstitial Lung Disease (ILD)-like events in patients taking Tarceva for the treatment of pancreatic cancer or other advanced solid tumors. Reports of these ILD-like lung injuries have been serious and have included deaths in some patients.

Possible effects on the kidneys and liver

Liver and/or kidney problems (including deaths) have been reported in some patients taking Tarceva. Let your doctor know if you have a history of liver or kidney disease.

Possible effects on the stomach and intestines

Holes that formed in the stomach, small intestine, or large bowel (including deaths) have been reported in patients taking Tarceva.

Possible effects on the skin

Severe blistering skin reactions including cases similar to Stevens-Johnson syndrome (including deaths) have been reported in patients taking Tarceva.

Possible effects on the veins and heart

Patients taking Tarceva plus gemcitabine were more likely to experience bleeding and clotting problems such as heart attack or stroke.

Possible effects on the eye

Eye irritation and damage to the cornea have been reported in patients taking Tarceva. Patients should tell their doctor about eye problems, including eye pain, that get worse.

Tarceva and pregnancy and breast-feeding

Tarceva may cause harm to an unborn baby or may cause possible risk of pregnancy loss. Women should avoid becoming pregnant and avoid breastfeeding while taking Tarceva.

When to call your HCP

Call your doctor right away if you have these signs or symptoms:

  • New or worsening skin rash
  • Serious or ongoing diarrhea, nausea, loss of appetite, vomiting, or stomach pain
  • New or worsening shortness of breath or cough
  • Fever
  • Eye irritation

If you smoke, you should stop smoking while taking Tarceva, as it may affect how well Tarceva works for you. If you continue to smoke you should speak to your doctor before taking Tarceva.

Let your doctor know if you are taking other prescription or over-the-counter drugs or herbal supplements before you start taking Tarceva. While taking Tarceva, do not start taking any new drugs or herbal supplements before talking to your doctor. Do not eat grapefruit or drink grapefruit juice while taking Tarceva. Tarceva may also affect other medications you are taking.

Common side effects of Tarceva

Fatigue, rash, nausea, loss of appetite, and diarrhea were the most common side effects associated with Tarceva plus gemcitabine therapy in a large clinical study.

Always let your doctor or nurse know if you experience any side effects. Ask your doctor or nurse for the best way to handle drug-related side effects.

Tarceva is not right for everyone. Ask your doctor if once-daily Tarceva is right for you.


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Tarceva® erlotinib tablets