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• Tarceva in combination with gemcitabine is prescribed for patients with advanced-stage pancreatic cancer whose cancer has spread, grown, or cannot be surgically removed and who have not received previous chemotherapy.

Everyone reacts differently to Tarceva therapy. So it’s important to know what the side effects are. Although some people may have a life-threatening side effect, most do not.

Your doctor will stop treatment if any serious side effects occur. Be sure to contact your healthcare team if you have symptoms related to these side effects.

• Interstitial lung disease (ILD)-like events
  Problems occurring in the lungs (including deaths). Tarceva may need to be stopped if new or unexplained serious symptoms of shortness of breath, cough, and fever occur.

• Liver and/or kidney problems
  Some events have included death. Let your healthcare provider (HCP) know if you have a history of liver or kidney disease.

• Gastrointestinal (GI) perforation
  A hole that develops in your stomach or intestine. Some events have included death.

• Serious skin conditions
  Some events have included death.

• Bleeding and clotting problems
  Heart attack or stroke in patients receiving Tarceva plus gemcitabine for advanced pancreatic cancer.

• Eye disorders
  Eye irritation and damage to the cornea.

• Bleeding events when taking warfarin
  Some events have included death. Tell your doctor if you are taking warfarin or non-steroidal anti-inflammatory drugs (NSAIDs).

• Pregnancy problems
  You should not become pregnant while on treatment with Tarceva. DO NOT breast-feed while receiving treatment with Tarceva.

Call your HCP right away if you have these signs or symptoms:

• New or worsening skin rash
• Serious or ongoing diarrhea, nausea, loss of appetite, or vomiting
• New or worsening shortness of breath or cough
• Eye irritation

The most common side effects are fatigue (feeling tired), rash, nausea, loss of appetite, and diarrhea.

It is important that you tell your HCP about all of the medicines and herbal supplements you are taking.

• DO NOT start taking any new medicines or herbal supplements before talking with your HCP.
• DO NOT eat grapefruit or drink grapefruit juice while on treatment with Tarceva, except under the care of your HCP.

Smoking may affect how well Tarceva works for you.

• If you smoke, you should stop smoking before starting treatment with Tarceva.
• If you continue to smoke, you should talk to your HCP before taking Tarceva.

Always let your HCP know if you have any side effects, and ask about the best way to handle them.

Tarceva is not right for everyone. Ask your HCP if once-daily Tarceva is right for you.

• Please see the Tarceva full Prescribing Information for additional Important Safety Information.

You may report side effects to the FDA at 1 (800) FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at 1 (888) 835-2555.